Maternal resveratrol consumption and its programming effects on metabolic health in offspring mechanisms and potential implications

作者：Sheng Zheng, Qianyun Feng, Jing Cheng, Jia Zheng · 发表于：Bioscience Reports · 年份：2018 · DOI：10.1042/bsr20171741 · 被引用次数：31 · 研究领域：Gestational Diabetes Research and Management、Birth, Development, and Health、Adipose Tissue and Metabolism

A growing body of evidence has clearly demonstrated that maternal nutrition can strongly determine the susceptibility to the development of metabolic diseases in offspring. With the increasing prevalence of maternal overweight, obesity, and gestational diabetes mellitus, it yields enormous burden for individual and public health. Interventions during pregnancy have been proven to be challenging, with limited efficacy and low compliance. Resveratrol, as a natural polyphenolic compound, has a wide-range of beneficial properties, including potent antiobesogenic, antiatherosclerotic, and antidiabetic effects. However, the role of maternal resveratrol intake on metabolic health in offspring has not been extensively investigated. Therefore, the aim of this study was to review the effects of maternal resveratrol supplementation on metabolic health in offspring and its potential mechanisms.