Use of deep neural network ensembles to identify embryonic-fetal transition markers: repression of COX7A1 in embryonic and cancer cells

作者：Michael D. West, Ivan Labat, Hal Sternberg, Dana Larocca, Igor O. Nasonkin, Karen Chapman, Ratnesh K. Singh, Eugene Makarev, Alex Aliper, Andrey Kazennov, Andrey Alekseenko, Nikolai Shuvalov, Evgenia Cheskidova, Aleksandr Alekseev, Artem V. Artemov, Evgeny Putin, Polina Mamoshina, Nikita Pryanichnikov, Jacob Larocca, Karen Copeland, Evgeny Izumchenko, Mikhail Korzinkin, Alex Zhavoronkov · 发表于：Oncotarget · 年份：2017 · DOI：10.18632/oncotarget.23748 · 被引用次数：50 · 研究领域：MicroRNA in disease regulation、Molecular Biology Techniques and Applications、Congenital heart defects research

// Michael D. West 1 , Ivan Labat 1 , Hal Sternberg 1 , Dana Larocca 1 , Igor Nasonkin 2 , Karen B. Chapman 3 , Ratnesh Singh 2 , Eugene Makarev 4 , Alex Aliper 4 , Andrey Kazennov 4, 5 , Andrey Alekseenko 4, 10 , Nikolai Shuvalov 4, 5 , Evgenia Cheskidova 4, 5 , Aleksandr Alekseev 4, 5 , Artem Artemov 4 , Evgeny Putin 4, 6 , Polina Mamoshina 4 , Nikita Pryanichnikov 4 , Jacob Larocca 1 , Karen Copeland 7 , Evgeny Izumchenko 8 , Mikhail Korzinkin 4 and Alex Zhavoronkov 4, 9 1 AgeX Therapeutics, Inc., Alameda, CA, USA 2 BioTime, Inc., Alameda, CA, USA 3 Johns Hopkins University, Baltimore, MD, USA 4 Pharmaceutical Artificial Intelligence Department, Insilico Medicine, Inc., Emerging Technology Centers, Johns Hopkins University at Eastern, Baltimore, MD, USA 5 Moscow Institute of Physics and Technology, Dolgoprudny, Russia 6 Computer Technologies Lab, ITMO University, St. Petersburg, Russia 7 Boulder Statistics, Boulder, CO, USA 8 Johns Hopkins University, School of Medicine, Department of Otolaryngology-Head and Neck Cancer Research, Baltimore, MD, USA 9 The Biogerontology Research Foundation, Trevissome Park, Truro, UK 10 Innopolis University, Innoplis, Russia Correspondence to: Michael D. West, email: mwest@biotimeinc.com Alex Zhavoronkov, email: alex@insilicomedicine.com Keywords: cancer marker; Warburg effect; embryonic-fetal transition; deep neural network; stem cells Received: September 18, 2017      Accepted: December 20, 2017   &...