Noralashinol B, a norlignan with cytotoxicity from stem barks of Syringa pinnatifolia

作者：Ruifei Zhang, Xiao Feng, Guo‐Zhu Su, Xu Yin, Xinyao Yang, Yunfang Zhao, Weifeng Li, Pengfei Tu, Xingyun Chai · 发表于：Journal of Asian Natural Products Research · 年份：2017 · DOI：10.1080/10286020.2017.1307188 · 被引用次数：17 · 研究领域：Phytochemistry and Biological Activities、Plant-derived Lignans Synthesis and Bioactivity、Natural product bioactivities and synthesis

One new norlignan, noralashinol B (1), and one new natural product, proposed noralashinol C (2), were isolated in a continuous phytochemical investigation on the stem barks of Syringa pinnatifolia. Their structures were elucidated based on the analysis of spectroscopic data, including mass spectrometry and 1D and 2D NMR spectroscopies, and the absolute configuration was determined by experimental and calculated electronic circular dichroism. Compound 1 showed a weak cytotoxicity against HepG2 hepatic cancer cells with its IC50 value of 31.7 μM. Furthermore, 1 induced apoptosis of HepG2 cells in a dose-dependent manner at concentrations of 0–80.0 μM.