Alashinols F and G, two lignans from stem bark of Syringa pinnatifolia

作者：Xiao Feng, Guo‐Zhu Su, Yunyun Ye, Ruifei Zhang, Xinyao Yang, Bing-Zhao Du, Bing Peng, Pengfei Tu, Xingyun Chai · 发表于：Natural Product Research · 年份：2017 · DOI：10.1080/14786419.2017.1283500 · 被引用次数：20 · 研究领域：Phytochemistry and Biological Activities、Natural product bioactivities and synthesis、Biological Activity of Diterpenoids and Biflavonoids

Two new lignans, alashinols F and G (1 and 2), together with two known analogues (-)-secoisolariciresinol (3) and meso-secoisolariciresinol (4) were isolated from the stem bark of Syringa pinnatifolia, a Mongolian folk medicine with anti-myocardial ischaemic effects. Their structures were elucidated on basis of spectroscopic data analyses, including MS and 1D and 2D NMR, and their absolute configurations were elucidated on the basis of experimental and calculated electronic circular dichroisms. The in vitro anti-inflammation and anti-hypoxia evaluations were also discussed.