Signal transduction by the SRC family of tyrosine protein kinases in hemopoietic cells.

作者：Joseph B. Bolen · 发表于：PubMed · 年份：1991 · 被引用次数：63 · 研究领域：Chronic Myeloid Leukemia Treatments、Cytokine Signaling Pathways and Interactions、Protein Kinase Regulation and GTPase Signaling

Signal transduction collectively encompasses the diverse biochemical reactions involved in modulating programmed cellular responses to external and internal stimuhi. Among the cellular enzymes involved in this complex process, the TPKs2 appear to play key roles in mediating signaling events that aid in the regulation of cell growth and differentiation. The TPKs can be divided into two major groups on the basis of their predicted structures. The first TPK group contains those that possess extracellular domains which generally function to bind peptide hormones. Examples of TPKs included in this group are the receptors for epidermal growth factor and plateletderived growth factor (reviewed in Ref. 1 ). The second TPK group contains those that lack extracellular domains and are categorized as the nonreceptor TPKs. Members of this group include the src family of TPKs as well as the members of the les/lps and abi gene families (reviewed in Refs. 2-4). The basic physiological function of the receptor TPKs to transduce peptide hormone binding into alterations in cellular metabolism is well established. However, only within the last 3 years has significant progress been made toward understanding potential physiological functions of at least a few members of the src family of nonreceptor TPKs. Normal physiological regulators of the les/lps and abl TPKs have not yet been reported. The purpose of this review is to briefly discuss the recent evidence that implicates several members of the...