High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity

作者：Vikram Pattanayak, Steven Lin, John P. Guilinger, Enbo Ma, Jennifer A. Doudna, David R. Liu · 发表于：Nature Biotechnology · 年份：2013 · DOI：10.1038/nbt.2673 · 被引用次数：1548 · 研究领域：CRISPR and Genetic Engineering、RNA Interference and Gene Delivery、RNA and protein synthesis mechanisms