Effect of Zaldaride Maleate, an Antidiarrheal Compound, on 16,16-Dimethyl Prostaglandin E2-Induced Intestinal Ion Secretion in Rats.

作者：Nobuo Aikawa, Akira Karasawa, Kenji Ohmori · 发表于：The Japanese Journal of Pharmacology · 年份：2000 · DOI：10.1254/jjp.83.269 · 被引用次数：2 · 研究领域：Ion Transport and Channel Regulation、Ion channel regulation and function、Pharmacological Effects of Natural Compounds

The effect of zaldaride, a calmodulin inhibitor, on 16,16-dimethyl prostaglandin E2 (dmPGE2)-induced intestinal ion secretion was investigated in rats. Zaldaride inhibited the dmPGE2-induced increase in water content in the colon, but not that in the small intestine. In the colonic mucosa, zaldaride attenuated the dmPGE2-induced short-circuit current; however, it did not affect the forskolin or dibutyryl cAMP-induced effect. These results suggest that zaldaride inhibits dmPGE2-induced intestinal ion secretion by reducing the activity of Ca2+/calmodulin-dependent adenylate cyclase linked to a receptor, and the colon may be an important site in the action of zaldaride.