Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration

作者：Simeon Bowers, Anh P. Truong, R. Jeffrey Neitz, Roy K. Hom, Jennifer M. Sealy, Gary D. Probst, David A. Quincy, Brian T. Peterson, Wayman Chan, Robert A. Galemmo, Andrei William Konradi, Hing Leung Sham, Gergely Tóth, Hu Pan, May H. Lin, Nanhua Yao, Dean R. Artis, Heather Zhang, Linda Chen, Mark Dryer, Bhushan Samant, Wes Zmolek, Karina Wong, Colin Lorentzen, Erich G. Goldbach, George Tonn, Kevin P. Quinn, John‐Michael Sauer, Sarah Wright, Kyle A. Powell, Lany Ruslim, Zhao Ren, Frédérique Bard, Ted A. Yednock, Irene Griswold‐Prenner · 发表于：Bioorganic & Medicinal Chemistry Letters · 年份：2011 · DOI：10.1016/j.bmcl.2011.06.100 · 被引用次数：33 · 研究领域：Computational Drug Discovery Methods、Synthesis of Tetrazole Derivatives、Melanoma and MAPK Pathways