4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

作者：Adrienne H. Long, Waleed M. Haso, Jack F. Shern, Kelsey Marie Wanhainen, Meera Murgai, Maria Ingaramo, Jillian P. Smith, Alec J. Walker, Mark Eric Kohler, Vikas R Venkateshwara, Rosandra Natasha Kaplan, George H. Patterson, Terry J. Fry, Rimas J. Orentas, Crystal Lee Mackall · 发表于：Nature Medicine · 年份：2015 · DOI：10.1038/nm.3838 · 被引用次数：1863 · 研究领域：CAR-T cell therapy research、Immune Cell Function and Interaction、T-cell and B-cell Immunology