Catalytic in vivo protein knockdown by small-molecule PROTACs

作者：Daniel P. Bondeson, Alina Mares, Ian E. Smith, Eunhwa Ko, Sébastien Campos, Afjal H. Miah, Katie E Mulholland, Natasha Routly, Dennis L. Buckley, Jeffrey L. Gustafson, Nico Zinn, Paola Grandi, Satoko Shimamura, Giovanna Bergamini, Maria Faelth-Savitski, Marcus Bantscheff, Carly S. Cox, Deborah A. Gordon, Ryan R. Willard, John J. Flanagan, Linda Casillas, Bartholomew J. Votta, Willem den Besten, Kristoffer Famm, Laurens Kruidenier, Paul S. Carter, John D. Harling, Ian Churcher, Craig M. Crews · 发表于：Nature Chemical Biology · 年份：2015 · DOI：10.1038/nchembio.1858 · 被引用次数：1366 · 研究领域：Protein Degradation and Inhibitors、Peptidase Inhibition and Analysis、Ubiquitin and proteasome pathways