Xian Chen

机构：Jiangnan University, University of North Carolina at Chapel Hill, Blue Cross Blue Shield of Massachusetts, Shanghai University of Engineering Science, Yunnan Institute For Drug Abuse, Wuxi Fourth People's Hospital, Segeberger Kliniken, UNC Lineberger Comprehensive Cancer Center

发表论文 196 篇 · 总被引 16339 次 · h-index 52

代表论文

• USP28-Based Deubiquitinase-Targeting Chimeras for Cancer Treatment (2025 · Journal of the American Chemical Society · 被引 24)
• Harnessing the Deubiquitinase USP1 for Targeted Protein Stabilization (2025 · Journal of the American Chemical Society · 被引 15)
• Harnessing the SPOP E3 Ubiquitin Ligase via a Bridged Proteolysis Targeting Chimera (PROTAC) Strategy for Targeted Protein Degradation (2025 · Journal of Medicinal Chemistry · 被引 14)
• Discovery of a Potent and Selective Protein Arginine Methyltransferase 5 (PRMT5) PROTAC Degrader (2025 · Journal of Medicinal Chemistry · 被引 11)
• Discovery of the first-in-class DOT1L PROTAC degrader (2025 · European Journal of Medicinal Chemistry · 被引 11)
• Segregated supramammillary-dentate gyrus circuits modulate cognitive and affective function in healthy and Alzheimer’s disease model mice (2025 · Neuron · 被引 10)