Jon Kuehler

机构：Mirati Therapeutics (United States)

发表论文 11 篇 · 总被引 430 次 · h-index 8

代表论文

• Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of MTAP -Deleted Cancers (2022 · Journal of Medicinal Chemistry · 被引 157)
• Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein–Protein Interaction (2022 · Journal of Medicinal Chemistry · 被引 96)
• Azaindole Hydroxamic Acids are Potent HIV-1 Integrase Inhibitors (2009 · Journal of Medicinal Chemistry · 被引 53)
• Design and Synthesis of Novel N-Hydroxy-Dihydronaphthyridinones as Potent and Orally Bioavailable HIV-1 Integrase Inhibitors (2011 · Journal of Medicinal Chemistry · 被引 43)
• Azaindole N-methyl hydroxamic acids as HIV-1 integrase inhibitors-II. The impact of physicochemical properties on ADME and PK (2010 · Bioorganic & Medicinal Chemistry Letters · 被引 23)
• Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3Kα Mutant Protein (2024 · Journal of Medicinal Chemistry · 被引 22)