Dennis S. Yamashita

机构：Vertero Therapeutics (United States)

发表论文 64 篇 · 总被引 3379 次 · h-index 26

代表论文

• A G Protein-Biased Ligand at the μ-Opioid Receptor Is Potently Analgesic with Reduced Gastrointestinal and Respiratory Dysfunction Compared with Morphine (2013 · Journal of Pharmacology and Experimental Therapeutics · 被引 668)
• Selectively Engaging β-Arrestins at the Angiotensin II Type 1 Receptor Reduces Blood Pressure and Increases Cardiac Performance (2010 · Journal of Pharmacology and Experimental Therapeutics · 被引 377)
• Structure–Activity Relationships and Discovery of a G Protein Biased μ Opioid Receptor Ligand, [(3-Methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the Treatment of Acute Severe Pain (2013 · Journal of Medicinal Chemistry · 被引 210)
• Identification of 4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a Novel Inhibitor of AKT Kinase (2008 · Journal of Medicinal Chemistry · 被引 160)
• Cathepsin K and the Design of Inhibitors of Cathepsin K (2000 · Current Pharmaceutical Design · 被引 138)
• A highly potent inhibitor of cathepsin K (relacatib) reduces biomarkers of bone resorption both in vitro and in an acute model of elevated bone turnover in vivo in monkeys (2006 · Bone · 被引 137)