Philip M. Pitis

机构：Prelude Therapeutics Incorporated (United States)

发表论文 17 篇 · 总被引 1023 次 · h-index 7

代表论文

• A G Protein-Biased Ligand at the μ-Opioid Receptor Is Potently Analgesic with Reduced Gastrointestinal and Respiratory Dysfunction Compared with Morphine (2013 · Journal of Pharmacology and Experimental Therapeutics · 被引 668)
• Structure–Activity Relationships and Discovery of a G Protein Biased μ Opioid Receptor Ligand, [(3-Methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the Treatment of Acute Severe Pain (2013 · Journal of Medicinal Chemistry · 被引 210)
• Aroyl(aminoacyl)pyrroles, a New Class of Anticonvulsant Agents (1997 · Journal of Medicinal Chemistry · 被引 57)
• Parallel methods for the preparation and SAR exploration of N-ethyl-4-[(8-alkyl-8-aza-bicyclo[3.2.1]oct-3-ylidene)-aryl-methyl]-benzamides, powerful mu and delta opioid agonists (2004 · Bioorganic & Medicinal Chemistry Letters · 被引 28)
• N , N -Dialkyl-4-[(8-azabicyclo[3.2.1]-oct-3-ylidene)phenylmethyl]benzamides, potent, selective δ opioid agonists (2004 · Bioorganic & Medicinal Chemistry Letters · 被引 19)
• The Novel, Orally Active, Delta Opioid RWJ-394674 Is Biotransformed to the Potent Mu Opioid RWJ-413216 (2006 · Journal of Pharmacology and Experimental Therapeutics · 被引 15)