Mild Behavioral Impairment and Cortical Thinning: Biomarkers of Early Neurodegeneration.

作者：Y. Leow, S. Saffari, A. Vipin, P. Tanoto, Rasyiqah Binte Shaik Mohamed Salim, Bocheng Qiu, Z. Ismail, N. Kandiah · 发表于：Biological Psychiatry: Cognitive Neuroscience and Neuroimaging · 年份：2025 · DOI：10.1016/j.bpsc.2025.06.010 · 被引用次数：7 · 研究领域：Medicine

BACKGROUND Mild Behavioral Impairment(MBI) is increasingly recognized as an early phenotypic marker of neurodegeneration, characterized by neuropsychiatric symptoms(NPS) emerging prior to overt cognitive decline. While structural neuroimaging studies link cortical thinning with NPS, the relationship between MBI and cortical morphology remains underexplored in diverse, community-based cohorts. This study investigated whether early behavioral alterations, assessed via the Mild Behavioral Impairment Checklist(MBI-C), correlate with region-specific cortical thinning in a Southeast Asian cohort. METHODS A cross-sectional analysis was conducted on 969 participants (mean age 61.99±10.19years;39.6% male;87.2%Chinese) from the Biomarkers and Cognition Study in Singapore(BIOCIS), spanning cognitively normal, subjective cognitive decline(SCD), and mild cognitive impairment(MCI). MBI was assessed using self-reported MBI-C. Cortical thickness was measured using T1-weighted MRI scans processed with FreeSurfer. Associations between cortical thinning and MBI-C total and subdomain scores were evaluated. RESULTS Higher scores on the MBI-C Belief subdomain were significantly associated with cortical thinning in the right hemisphere(β=-0.0177;95%CI:-0.0342to-0.0012;P=0.035). Region-specific analyses showed temporal lobe thinning in the posterior superior temporal sulcus, fusiform gyrus, superior temporal gyrus, temporal pole, and transverse temporal gyrus, and associations remained significa...