A mechanism-based operational definition and classification of hypercholesterolemia.

作者：F. Civeira, M. Arca, A. Cenarro, R. Hegele · 发表于：Journal of Clinical Lipidology · 年份：2022 · DOI：10.1016/j.jacl.2022.09.006 · 被引用次数：82 · 研究领域：Medicine

In contrast to strong evidence-based clinical recommendations for lipid-lowering treatment, there is no analogous definitive diagnostic definition of hypercholesterolemia and its various subtypes. For many clinicians, guideline indications for hypolipidemic treatment can become broadly conflated with hypercholesterolemia in a non-specific sense. In this statement, we propose a unified definition and mechanism-based classification of hypercholesterolemia, which in turn should help to stratify patients and guide efficient diagnosis without interfering with the current strategies of ASCVD risk reduction.