Age- and Sex-Specific Myocardial Blood Flow Values in Patients Without Coronary Atherosclerosis on Rb-82 PET Myocardial Perfusion Imaging

作者：MD Brett W. Sperry, MD Mark P. Metzinger, MD Ali O. Ibrahim, MD Randall C. Thompson, MS Yoon J. Cho, MS Phillip G. Jones, MD A. Iain McGhie, MD Timothy M. Bateman · 发表于：Circulation Cardiovascular Imaging · 年份：2024 · DOI：10.1161/circimaging.124.016577 · 被引用次数：21 · 研究领域：Medicine

BACKGROUND: Quantitative myocardial blood flow (MBF) on positron-emission tomography myocardial perfusion imaging is a measure of the overall health of the coronary circulation. The ability to adequately augment blood flow, measured by myocardial blood flow reserve (MBFR), is associated with lower major adverse cardiovascular events and all-cause mortality. The age-specific ranges of MBFR in patients without demonstrable coronary artery disease have not been well established. We aimed to determine the effect of age and sex on MBF in a cohort of patients without demonstrable coronary artery disease. METHODS: Patients who underwent positron-emission tomography myocardial perfusion imaging studies from 2012 to 2022 on positron-emission tomography/computed tomography cameras were included if the summed stress score was 0, the coronary calcium score was 0, and the left ventricular ejection fraction was ≥50%. Those with known coronary artery disease, prior history of coronary intervention, diabetes, heart/kidney/liver transplant, cirrhosis, or chronic kidney disease stage IV+ were excluded. MBF was calculated using a net retention model (ImagenQ, Cardiovascular Imaging Technologies, Kansas City), and quantile regression models were developed to predict MBF. RESULTS: Among 2789 patients (age 59.9±13.0 years, 76.4% females), median rest MBF was 0.73 (0.60–0.91) mL/min·g, stress MBF was 1.72 (1.41–2.10) mL/min·g, and MBFR was 2.31 (1.96–2.74). Across all ages, males augmented MBF in r...