Regio- and Enantioselective Nickel-Catalyzed Ipso- and Remote Hydroamination Utilizing Organic Azides as Amino Sources for the Synthesis of Primary Amines.

作者：Shi-Chao Wang, Lin Liu, M. Duan, Weijia Xie, Jiabin Han, Yuhang Xue, You Wang, Xiaotai Wang, Shaolin Zhu · 发表于：Journal of the American Chemical Society · 年份：2024 · DOI：10.1021/jacs.4c12324 · 被引用次数：25 · 研究领域：Medicine

Primary amines serve as key synthetic precursors to most other N-containing compounds, which are important in organic and medicinal chemistry. Herein, we present a NiH-catalyzed mild ipso- and remote hydroamination technique that utilizes organic azides as deprotectable primary amine sources. This strategy offers a highly flexible platform for the efficient construction of α-chiral branched primary amines, as well as linear primary amines.