Global, regional, and national burden of osteoarthritis, 1990–2020 and projections to 2050: a systematic analysis for the Global Burden of Disease Study 2021

作者：Jaimie D Steinmetz, Garland T. Culbreth, Lydia M Haile, Quinn Rafferty, Justin Lo, K. Fukutaki, Jessica Cruz, Amanda E Smith, S. Vollset, P. M. Brooks, M. Cross, A. Woolf, Hailey Hagins, M. Abbasi-Kangevari, Aidin Abedi, I. Ackerman, Hubert Amu, B. Antony, J. Arabloo, A. Aravkin, A. Argaw, A. Artamonov, Tahira Ashraf, Amadou Barrow, L. Bearne, I. Benseñor, Alemshet Yirga Berhie, Nikha Bhardwaj, Pankaj Bhardwaj, Vijayalakshmi S. Bhojaraja, Ali Bijani, P. Briant, A. Briggs, Nadeem Shafique Butt, J. Charan, Vijay Kumar Chattu, F. Cicuttini, Kaleb Coberly, O. Dadras, X. Dai, L. Dandona, R. Dandona, K. de Luca, E. Denova-Gutiérrez, S. Dharmaratne, M. Dhimal, M. Dianatinasab, K. Dreinhoefer, Muhammed Elhadi, Umar Farooque, H. Farpour, I. Filip, F. Fischer, M. Freitas, Balasankar Ganesan, Belete Negese Belete Gemeda, Tamiru Getachew, S. Ghamari, A. Ghashghaee, T. Gill, Mahaveer Golechha, D. Golinelli, Bhawna Gupta, Veera Gupta, Vikrant Gupta, Rasool Haddadi, N. Hafezi-Nejad, R. Halwani, Samer Hamidi, Asif Hanif, N. I. Harlianto, J. Haro, J. Hartvigsen, Simon Iain Hay, J. Hébert, G. Heidari, Mohammad-Salar Hosseini, M. Hosseinzadeh, A. Hsiao, I. Ilic, M. Ilic, L. Jacob, R. Jayawardena, Ravi Prakash Jha, J. Jonas, N. Joseph, Himal Kandel, Ibraheem M. Karaye, Md Jobair Khan, Y. Kim, Ali-Asghar Kolahi, O. Korzh, Rajasekaran Koteeswaran, V. Krishnamoorthy, G. Kumar, Narinder Kumar, Sang-Woong Lee, Stephen S. Lim, S. Lobo, G. Lucchetti, M. Malekpour, A. A. Malik, L. G. Mandarano-Filho, S. Martini, A. Mentis, Mohamed Mesregah MD, T. Meštrović, E. Mirrakhimov, A. Misganaw, R. Mohammadpourhodki, A. Mokdad, S. Momtazmanesh, S. Morrison, C. Murray, H. Nassereldine, Henok Biresaw Netsere, Sandhya Neupane Kandel, M. Owolabi, S. Panda-Jonas, Anamika Pandey, Shrikant Pawar, P. Pedersini, Jeevan Pereira, A. Radfar, M. Rashidi, D. Rawaf, S. Rawaf, R. Rawassizadeh, S. Rayegani, Daniel Ribeiro, Leonardo Roever, B. Saddik, A. Sahebkar, Salehi, L. SÀNCHEZ RIERA, F. Sanmarchi, Milena M. Santric-Milicevic, S. Shahabi, M. Shaikh, Elaheh Shaker, Mohammed Shannawaz, Rajendra Sharma, Saurabh Sharma, J. Shetty, R. Shiri, P. Shobeiri, D. Silva, A. Singh, Jasvinder A. Singh, Surjit Singh, S. T. Skou, H. Slater, M. Soltani‐Zangbar, A. Starodubova, A. Tehrani-Banihashemi, Sahel Valadan Tahbaz, Pascual Valdez, B. Võ, L. Vu, Yuan-Pang Wang, Seyed Hossein Yahyazadeh Jabbari, N. Yonemoto, Ismaeel Yunusa, L. March, K. Ong, T. Vos, J. Kopec · 发表于：The Lancet Rheumatology · 年份：2023 · DOI：10.1016/s2665-9913(23)00163-7 · 被引用次数：1332 · 研究领域：Medicine

Summary Background Osteoarthritis is the most common form of arthritis in adults, characterised by chronic pain and loss of mobility. Osteoarthritis most frequently occurs after age 40 years and prevalence increases steeply with age. WHO has designated 2021–30 the decade of healthy ageing, which highlights the need to address diseases such as osteoarthritis, which strongly affect functional ability and quality of life. Osteoarthritis can coexist with, and negatively effect, other chronic conditions. Here we estimate the burden of hand, hip, knee, and other sites of osteoarthritis across geographies, age, sex, and time, with forecasts of prevalence to 2050. Methods In this systematic analysis for the Global Burden of Disease Study, osteoarthritis prevalence in 204 countries and territories from 1990 to 2020 was estimated using data from population-based surveys from 26 countries for knee osteoarthritis, 23 countries for hip osteoarthritis, 42 countries for hand osteoarthritis, and US insurance claims for all of the osteoarthritis sites, including the other types of osteoarthritis category. The reference case definition was symptomatic, radiographically confirmed osteoarthritis. Studies using alternative definitions from the reference case definition (for example self-reported osteoarthritis) were adjusted to reference using regression models. Osteoarthritis severity distribution was obtained from a pooled meta-analysis of sources using the Western Ontario and McMaster Universi...