MOGONET integrates multi-omics data using graph convolutional networks allowing patient classification and biomarker identification

作者：Tongxin Wang, Wei Shao, Zhi Huang, Haixu Tang, J. Zhang, Zhengming Ding, Kun Huang · 发表于：Nature Communications · 年份：2021 · DOI：10.1038/s41467-021-23774-w · 被引用次数：619 · 研究领域：Medicine

To fully utilize the advances in omics technologies and achieve a more comprehensive understanding of human diseases, novel computational methods are required for integrative analysis of multiple types of omics data. Here, we present a novel multi-omics integrative method named Multi-Omics Graph cOnvolutional NETworks (MOGONET) for biomedical classification. MOGONET jointly explores omics-specific learning and cross-omics correlation learning for effective multi-omics data classification. We demonstrate that MOGONET outperforms other state-of-the-art supervised multi-omics integrative analysis approaches from different biomedical classification applications using mRNA expression data, DNA methylation data, and microRNA expression data. Furthermore, MOGONET can identify important biomarkers from different omics data types related to the investigated biomedical problems. Our understanding of human disease can be improved by integrating the abundance of high throughput biomedical data. Here, the authors use deep learning methods successfully used on images to integrate various types of omics data to improve patient classification and identify disease biomarkers.