Clinical Characteristics of Coronavirus Disease 2019 in China

作者：Wei-Jie Guan, Zheng-yi Ni, Yu Hu, Wen-Hua Liang, Chun-Quan Ou, Jian-xing He, Lei Liu, Hongxuan Shan, C. Lei, D. S. Hui, Bin Du, Lan-juan Li, Guang-qiao Zeng, Kwok-Yung Yuen, Ruchong Chen, Chun-li Tang, Tao Wang, Ping Chen, J. Xiang, Shi-Yue Li, Jin-lin Wang, Zi-jing Liang, Yi-xiang Peng, Li Wei, Yong Liu, Ya-hua Hu, Peng Peng, Jian-ming Wang, Jiyong Liu, Zhong Chen, Gang Li, Zhi Zheng, Shao-qin Qiu, Jie Luo, Chang Ye, Shao-yong Zhu, Nan-shan Zhong · 发表于：New England Journal of Medicine · 年份：2020 · DOI：10.1056/NEJMoa2002032 · 被引用次数：3663 · 研究领域：Medicine

Abstract Background Since December 2019, when coronavirus disease 2019 (Covid-19) emerged in Wuhan city and rapidly spread throughout China, data have been needed on the clinical characteristics of the affected patients. Methods We extracted data regarding 1099 patients with laboratory-confirmed Covid-19 from 552 hospitals in 30 provinces, autonomous regions, and municipalities in mainland China through January 29, 2020. The primary composite end point was admission to an intensive care unit (ICU), the use of mechanical ventilation, or death. Results The median age of the patients was 47 years; 41.9% of the patients were female. The primary composite end point occurred in 67 patients (6.1%), including 5.0% who were admitted to the ICU, 2.3% who underwent invasive mechanical ventilation, and 1.4% who died. Only 1.9% of the patients had a history of direct contact with wildlife. Among nonresidents of Wuhan, 72.3% had contact with residents of Wuhan, including 31.3% who had visited the city. The most common symptoms were fever (43.8% on admission and 88.7% during hospitalization) and cough (67.8%). Diarrhea was uncommon (3.8%). The median incubation period was 4 days (interquartile range, 2 to 7). On admission, ground-glass opacity was the most common radiologic finding on chest computed tomography (CT) (56.4%). No radiographic or CT abnormality was found in 157 of 877 patients (17.9%) with nonsevere disease and in 5 of 173 patients (2.9%) with severe disease. Lymphocytopenia wa...