ASSOCIATION STUDY OF EPAS1 GENE POLYMORPHISMS WITH THE SUSCEPTIBILITY TO HIGH ALTITUDE PULMONARY HYPERTENSION IN TIBETAN RESIDENTS

作者：Qiling Gou, Hui Xue · 发表于：Journal of Hypertension · 年份：2025 · DOI：10.1097/01.hjh.0001117280.31257.2e · 被引用次数：1

Design and method: The study included 9,915 participants with systolic blood pressure below 130 mmHg and aged over 18 years with hypertension from the US National Health and Nutrition Examination Survey (NHANES) database between 1999 and 2018. Participants were stratified into three DBP level groups. Kaplan-Meier survival curves were used to illustrate mortality distribution over time in each group. The weighted univariate and multivariate Cox regression analyses were conducted to determine the association between different diastolic blood pressure levels and all-cause and cardiovascular mortality. Additionally, restricted cubic spline analysis was applied to investigate the detailed association between DBP and hazard ratio (HR). Results: A total of 9915 patients were categorized based on their average DBP into three groups: <60 mmHg (n=2618; ILDBP), 60 to 79 mmHg (n=6208), and >=80 mmHg (n=1089; IHDBP). After weighted, the overall mean age of the participants was 58±14 years, including 47.1% male and 77.4% non-Hispanic white. Over a median follow-up period of 101.7 months, the all-cause mortality was 28.6%. Multivariate Cox regression indicated that, after adjusting for common traditional risk factors, DBP <60 mmHg was associated with a higher risk of all-cause death (HR, 1.88; 95% CI, 1.67–2.11) and cardiovascular death (HR, 1.46; 95% CI, 1.23–1.73) compared to those with DBP between 60 and 79 mmHg. Kaplan-Meier survival curves demonstrated a progressive increase in both al...