Effects of Individual Circulating FFAs on Plasma Oxylipin Levels: Implications for FFA Epoxide‐diol Ratios as Indices of Soluble Epoxide Hydrolase Activity

作者：J. Youn, Jun Yang, Bruce Hammock, Youngtaek Oh · 发表于：The FASEB Journal · 年份：2022 · DOI：10.1096/fasebj.2022.36.s1.l7627 · 研究领域：Medicine

Oxylipins, oxidation products of essential free fatty acids (FFAs), are involved in various cellular signaling. Among them, FFA epoxides are associated with beneficial effects in metabolic and cardiovascular health. FFA epoxides are metabolized to usually biologically less active diols by soluble epoxide hydrolase (sEH). Inhibition of sEH, which increases FFA epoxides, improves glucose homeostasis and cardiovascular health. Plasma epoxide‐diol ratios have been used as indices of sEH activity.