The human body at cellular resolution: the NIH Human Biomolecular Atlas Program

作者：M. Snyder, Shin Lin, A. Posgai, M. Atkinson, A. Regev, Jennifer E. Rood, O. Rozenblatt-Rosen, L. Gaffney, A. Hupalowska, R. Satija, Nils Gehlenborg, J. Shendure, J. Laskin, P. Harbury, Nicholas A. Nystrom, J. Silverstein, Z. Bar-joseph, Kun Zhang, K. Börner, Yiing Lin, R. Conroy, Dena Procaccini, Ananda L. Roy, Ajay Pillai, Marishka Brown, Z. Galis, L. Cai, C. Trapnell, Dana L. Jackson, G. Nolan, W. Greenleaf, S. Plevritis, S. Ahadi, Stephanie A. Nevins, Hayan Lee, C. Schuerch, Sarah Black, V. Venkataraaman, Ed Esplin, Aaron M. Horning, A. Bahmani, Xin Sun, Sanjay Jain, J. Hagood, Gloria S. Pryhuber, P. Kharchenko, B. Bodenmiller, T. Brusko, M. Clare-Salzler, H. Nick, K. Otto, C. Wasserfall, Marda L. Jorgensen, Maigan A. Brusko, S. Maffioletti, R. Caprioli, J. Spraggins, Danielle B. Gutierrez, N. Patterson, Elizabeth K. Neumann, Raymond C. Harris, M. deCaestecker, A. Fogo, R. V. D. Plas, Ken Lau, Guocheng Yuan, Qian Zhu, Ruben Dries, Peng Yin, Sinem K. Saka, Jocelyn Y. Kishi, Yu Wang, I. Goldaracena, DongHye Ye, Kristin E. Burnum-Johnson, P. Piehowski, C. Ansong, Ying Zhu, T. Desai, J. Mulye, Peter Chou, Monica Nagendran, S. Teichmann, B. Paten, R. Murphy, Jian Ma, V. Kiselev, Carl Kingsford, A. Ricarte, M. Keays, Sushma A. Akoju, Matthew Ruffalo, Margaret Vella, C. McCallum, Leonard E. Cross, Samuel H. Friedman, Randy W. Heiland, B. Herr, P. Macklin, Ellen M. Quardokus, Lisel Record, J. Sluka, G. Weber, Philip D. Blood, A. Ropelewski, William Shirey, Robin M. Scibek, Paula M. Mabee, W. Lenhardt, K. Robasky, Stavros Michailidis, J. Marioni, Andrew W. Butler, Tim Stuart, Eyal Fisher, S. Ghazanfar, Gökçen Eraslan, Tommaso Biancalani, E. D. Vaishnav, P. Srinivas, A. Pawlyk, S. Sechi, Elizabeth L. Wilder, James Anderson · 发表于：Nature · 年份：2019 · DOI：10.1038/s41586-019-1629-x · 被引用次数：543 · 研究领域：Art、Biology、Mathematics、Computer Science、Medicine

Transformative technologies are enabling the construction of three-dimensional maps of tissues with unprecedented spatial and molecular resolution. Over the next seven years, the NIH Common Fund Human Biomolecular Atlas Program (HuBMAP) intends to develop a widely accessible framework for comprehensively mapping the human body at single-cell resolution by supporting technology development, data acquisition, and detailed spatial mapping. HuBMAP will integrate its efforts with other funding agencies, programs, consortia, and the biomedical research community at large towards the shared vision of a comprehensive, accessible three-dimensional molecular and cellular atlas of the human body, in health and under various disease conditions. HuBMAP supports technology development, data acquisition, and spatial analyses to generate comprehensive molecular and cellular three-dimensional tissue maps.