Associations of Blood Cadmium Levels With Osteoarthritis Among US Adults in NHANES 2013–2018

作者：Li-Jun Li, Jian-Gang Cao, Lin Li, Guang Wu, Junhui Xiao · 发表于：Journal of Occupational and Environmental Medicine · 年份：2024 · DOI：10.1097/jom.0000000000003135 · 被引用次数：2 · 研究领域：Medicine

There was a dose-response relationship between blood cadmium (BCd) concentration and osteoarthritis (OA), and the risk of OA increased with the increase of BCd concentration. This provides theoretical evidence for the clinical prevention of osteoarthritis against BCd. Background Osteoarthritis (OA) is a global public health problem, and limited information is available on the effects of Cd on OA. The purpose of this study is to explore the relationship between Cd and OA. Method Weighted multivariable logistic regression model, trend test, restricted cubic spline, and stratified analysis were used to study the association between BCd and OA. Results In the two regression models of weighted multivariable logistic regression analysis, the correlation between BCd and OA was positive. Compared with the lowest quartile of BCd exposure, the highest quartile had a 2.03-fold (95% confidence interval, 1.67 to 2.47), displaying a dose-response relationship (P for trend <0.00001). The restrictive cubic spline shows a positive linear relationship between BCd and OA. Conclusion There was a positive linear relationship between BCd and OA and a dose-response relationship.