Safety and efficacy of continuous intra-arterial infusion of heparin administration in mechanical thrombectomy for acute ischemic stroke: a single-center retrospective study

作者：Tao Meng, Xuefei Wang, Liu Yang, Jinping Wang, Pei Wang, Hui Wang, Yueqin Zhou, O. Cheng · 发表于：Frontiers in Neurology · 年份：2026 · DOI：10.3389/fneur.2025.1736654 · 研究领域：Medicine

Background and purpose The use of heparin during mechanical thrombectomy (MT) for acute large vessel occlusion ischemic stroke (LVO-AIS) is controversial, with no unified standard on its administration methods and efficacy. This study aims to investigate the effectiveness and safety of continuous intra-arterial infusion of heparin administration during MT in real-world practice. Materials and methods A single-center retrospective study included consecutive LVO stroke patients treated with mechanical thrombectomy at Chongqing University Central Hospital (August 2022–January 2024). Participants were stratified by intraprocedural heparin administration: (1) arterial heparin Group-continuous intra-arterial heparinization via high-pressure infusion (Heparin 1,000 IU was diluted in 500 ml of 0.9% sodium chloride solution and connected to both the guiding catheter and the intermediate catheter. The infusion bag was replaced as needed according to the duration of the procedure) at a conventional drip rate; (2) non-additional heparin Group-standard heparin solution flushing withoutusing additional anticoagulant. The main outcome were 3-months functional independence, defined as a modified Rankin Scale (mRS) ≤ 2. The main Safety outcome were defined as symptomatic intracranial hemorrhage (sICH) in 24 h. Results A total of 98 patients were eligible for analysis: 54 in the Arterial heparin Group and 44 in the Non-additional heparin Group. Continuous intra-arterial infusion of heparin adm...