Ankle Brachial Index Combined with Framingham Risk Score to Predict Cardiovascular Events and Mortality: A Meta-analysis

作者：F. Fowkes, G. Murray, I. Butcher, C. Heald, Lee Rj, L. Chambless, A. Folsom, A. Hirsch, M. Dramaix, G. Debacker, J. Wautrecht, M. Kornitzer, A. Newman, M. Cushman, K. Sutton-Tyrrell, Amanda J. Lee, J. Price, R. D’Agostino, J. Murabito, P. Norman, K. Jamrozik, J. Curb, K. Masaki, B. Rodríguez, J. Dekker, L. Bouter, R. Heine, G. Nijpels, C. Stehouwer, Leah M. Ferrucci, M. McDermott, H. Stoffers, Hooi Jd, J. Knottnerus, M. Ogren, B. Hedblad, J. Witteman, M. Breteler, M. Hunink, A. Hofman, M. Criqui, R. Langer, A. Fronek, W. Hiatt, R. Hamman, H. Resnick, J. Guralnik · 发表于：Journal of the American Medical Association (JAMA) · 年份：2008 · DOI：10.1001/jama.300.2.197 · 被引用次数：1859 · 研究领域：Medicine

Context Prediction models to identify healthy individuals at high risk of cardiovascular disease have limited accuracy. A low ankle brachial index is an indicator of atherosclerosis and has the potential to improve prediction. Objective To determine if the ankle brachial index provides information on the risk of cardiovascular events and mortality independently of the Framingham Risk Score and can improve risk prediction. Data Sources Relevant studies were identified by collaborators. A search of MEDLINE (1950 to February 2008) and EMBASE (1980 to February 2008), was conducted using common text words for the term ‘ABI’ combined with text words and Medical Subject Headings to capture prospective cohort designs. Review of reference lists and conference proceedings, and correspondence with experts was conducted to identify additional published and unpublished studies. Study Selection Studies were included if (1) participants were derived from a general population (2) ankle brachial index was measured at baseline and (3) subjects were followed up to detect total and cardiovascular mortality. Data Extraction Pre-specified data on subjects in each selected study were extracted into a combined dataset and an individual participant data meta-analysis conducted on subjects who had no previous history of coronary heart disease. Results Sixteen population cohort studies fulfilling the inclusion criteria were included. During 480,325 person years of follow up of 24,955 men and 23,339 wom...