Association of Enlarged Perivascular Spaces With Early Serum and Neuroimaging Biomarkers of Alzheimer Disease Pathology

作者：Justin Jit Hong Ong, Y. Leow, Bocheng Qiu, Pricilia Tanato, F. Zailan, G. Sandhu, N. Kandiah · 发表于：Neurology · 年份：2025 · DOI：10.1212/WNL.0000000000213836 · 被引用次数：6 · 研究领域：Medicine

Background and Objectives Enlarged perivascular spaces (EPVS), recognized as a key feature of cerebral small vessel disease (CSVD), have emerged as a promising biomarker for vascular contribution to Alzheimer disease (AD) and other neurodegenerative diseases. Although previous studies have linked EPVS to cerebrovascular dysfunction, their relationship with AD pathology and cognitive decline remains underexplored, particularly in multiethnic cohorts. This study investigates the associations between basal ganglia EPVS burden, blood-based biomarkers (BBM), and cognitive outcomes in a Southeast Asian cohort. Methods This cross-sectional study drew from the Biomarkers and Cognition Study, Singapore, comprising participants recruited from the community, at Dementia Research Centre (Singapore) from 2022 to 2024. Participants underwent comprehensive neuropsychologic assessments and were classified into cognitively normal, subjective cognitive decline, and mild cognitive impairment (MCI) groups according to established diagnostic criteria. BBM including amyloid β oligomers, amyloid β42 (Aβ42) and β40 (Aβ40), phosphorylated tau 181 (p-tau181), neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP) were quantified. MRI Markers of CSVD (EPVS, white matter hyperintensities [WMH], lacunes, and microbleeds) were visually rated using validated scales. Associations between EPVS, biomarkers, and cognitive outcomes were analyzed using correlation or multivariable regression...