ANXA2 in cancer: aberrant regulation of tumour cell apoptosis and its immune interactions

作者：Le Huang, Kai-Feng Xu, Qingping Yang, Zijun Ding, Zhenduo Shao, Enliang Li · 发表于：Cell Death Discovery · 年份：2025 · DOI：10.1038/s41420-025-02469-x · 被引用次数：17 · 研究领域：Medicine

Annexin A2 (ANXA2) is a multifunctional protein that binds to calcium and phospholipids and plays a critical role in various pathological conditions, including cancer and inflammation. Recently, there has been increasing recognition of the significant role of ANXA2 in inhibiting apoptosis and promoting immune evasion in tumour cells. Therefore, a deep understanding of the regulatory mechanisms of ANXA2 in tumour cell apoptosis and its relationship with immune evasion can provide new targets for cancer therapy. This review summarizes the role and mechanisms of ANXA2 in regulating apoptosis in tumour cells, the connection between apoptosis regulation and tumour immunity, and the potential role of ANXA2 in therapy resistance.