Relationship between magnesium intake and decline in kidney function, incident chronic kidney disease and incident cardiovascular disease

作者：Javier A Neyra, R. Katz, Stephen B. Kritchevsky, Joachim H. Ix, M. Shlipak, Anne B Newman, A. Hoofnagle, Linda F. Fried, Robert D. Toto, Orson W. Moe, M. Sarnak, Orlando M. Gutiérrez, David A Drew · 发表于：Clinical Kidney Journal · 年份：2025 · DOI：10.1093/ckj/sfaf144 · 被引用次数：1 · 研究领域：Medicine

ABSTRACT Background and hypothesis Higher magnesium (Mg) intake is associated with a lower risk of stroke, heart failure and mortality, while there are limited data with kidney disease outcomes. We hypothesized that higher dietary Mg intake would be associated with a lower incidence of cardiovascular disease (CVD), chronic kidney disease (CKD) and kidney function decline. Methods The Health, Aging, and Body Composition Study is an observational cohort of 3075 community-dwelling older adults. Dietary Mg intake was estimated using validated dietary surveys. Kidney outcomes included ≥30% decline in estimated glomerular filtration rate (eGFR) cystatin or incident CKD, which was defined as a subsequent eGFR <60 mL/min/1.73 m2 and at least 1 mL/min/year decline from baseline. Incident CVD was defined as incident coronary disease, heart failure, stroke or cardiovascular mortality. Multivariable Poisson regression and Cox proportional hazards models were used to evaluate the association of Mg intake with kidney and cardiovascular outcomes, respectively. Results After excluding missing data, 2682 individuals were available for analysis. The median daily dietary Mg intake was 278 mg/day (11.4 mmol/day) (25th–75th percentile: 214–350 mg/day). Among 1871 individuals without baseline CKD, 522 developed incident CKD, while within the whole cohort, 394 (14.7%) had a ≥30% decline in eGFR over 10 years. Higher Mg intake was independently associated with lower risk of 30% eGFR decline [inciden...