SNHG7 interacts with PCBP2 to promote CDKN2A expression and modulate cuproptosis in colorectal cancer

作者：Qiusan Chen, Qiuyu Song, Haonan Zhang, Zhaoxian Lin, Yulu Shi, Yixia Chai, Xianmei Fang, Na Li, Yifeng Zheng, Yi Yang, Xueying Wu, Shanping Wang, Chengcheng He, Mingsong Li · 发表于：Translational Oncology · 年份：2026 · DOI：10.1016/j.tranon.2026.102724 · 被引用次数：1 · 研究领域：Medicine

Highlights • SNHG7 interacts with PCBP2 to enhance CDKN2A expression in colorectal cancer (CRC).• CDKN2A regulates cuproptosis, a recently identified cell death pathway in CRC.• SNHG7 promotes glycolysis, contributing to CRC progression.• PCBP2 stabilizes RNA, playing a key role in tumorigenesis.• SNHG7 may serve as a therapeutic target for CRC treatment.• *Corresponding author.