Multi-Omics Approaches Against Abiotic and Biotic Stress—A Review

作者：Venkatramanan Varadharajan, Radhika Rajendran, Pandiyan Muthuramalingam, Ashish Runthala, Venkatesh Madhesh, Gowtham Swaminathan, P. Murugan, H. Srinivasan, Yeonju Park, Hyunsuk Shin, Manikandan Ramesh · 发表于：Plants · 年份：2025 · DOI：10.3390/plants14060865 · 被引用次数：92 · 研究领域：Medicine

Plants face an array of environmental stresses, including both abiotic and biotic stresses. These stresses significantly impact plant lifespan and reduce agricultural crop productivity. Abiotic stresses, such as ultraviolet (UV) radiation, high and low temperatures, salinity, drought, floods, heavy metal toxicity, etc., contribute to widespread crop losses globally. On the other hand, biotic stresses, such as those caused by insects, fungi, and weeds, further exacerbate these challenges. These stressors can hinder plant systems at various levels, including molecular, cellular, and development processes. To overcome these challenges, multi-omics computational approaches offer a significant tool for characterizing the plant’s biomolecular pool, which is crucial for maintaining homeostasis and signaling response to environmental changes. Integrating multiple layers of omics data, such as proteomics, metabolomics, ionomics, interactomics, and phenomics, simplifies the study of plant resistance mechanisms. This comprehensive approach enables the development of regulatory networks and pathway maps, identifying potential targets for improving resistance through genetic engineering or breeding strategies. This review highlights the valuable insights from integrating multi-omics approaches to unravel plant stress responses to both biotic and abiotic factors. By decoding gene regulation and transcriptional networks, these techniques reveal critical mechanisms underlying stress toleranc...