Ferroptotic therapy in cancer: benefits, side effects, and risks

作者：Jian-Dong Diao, Yuanyuan Jia, Enyong Dai, Jiao Liu, Rui Kang, D. Tang, Leng Han, Yingjie Zhong, Lingjun Meng · 发表于：Molecular Cancer · 年份：2024 · DOI：10.1186/s12943-024-01999-9 · 被引用次数：110 · 研究领域：Medicine

Ferroptosis is a type of regulated cell death characterized by iron accumulation and uncontrolled lipid peroxidation, leading to plasma membrane rupture and intracellular content release. Originally investigated as a targeted therapy for cancer cells carrying oncogenic RAS mutations, ferroptosis induction now exhibits potential to complement chemotherapy, immunotherapy, and radiotherapy in various cancer types. However, it can lead to side effects, including immune cell death, bone marrow impairment, liver and kidney damage, cachexia (severe weight loss and muscle wasting), and secondary tumorigenesis. In this review, we discuss the advantages and offer an overview of the diverse range of documented side effects. Furthermore, we examine the underlying mechanisms and explore potential strategies for side effect mitigation.