PKM2 Lactylation Promotes Colorectal Cancer Vasculogenic Mimicry and Bevacizumab Resistance by Facilitating FOSL1 Super-enhancer Formation

作者：Weihao Li, Jianhong Peng, Jiahua He, Leen Liao, Da Kang, Weili Zhang, Weifeng Wang, Ruowei Wang, Song Wang, Yuanbin Liao, Longjiang Yu, Qingjian Ou, Yujing Fang, Xiaojun Wu, Peirong Ding, Zhizhong Pan, Chi Zhou, Junzhong Lin · 发表于：Cancer Research · 年份：2026 · DOI：10.1158/0008-5472.can-25-3520 · 被引用次数：5 · 研究领域：Medicine

PKM2 lactylation mediates vasculogenic mimicry by facilitating FOSL1-dependent super-enhancer formation and represents a potential target to improve the clinical efficacy of bevacizumab in colorectal cancer patients.