Immune Correlates of Protection by mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates

作者：Kizzmekia S. Corbett, M. Nason, B. Flach, M. Gagne, S. O'connell, T. Johnston, Shruti N. Shah, V. Edara, K. Floyd, L. Lai, C. McDanal, J. Francica, Barbara Flynn, Kai Wu, A. Choi, M. Koch, O. Abiona, Anne P. Werner, Juan I. Moliva, Shayne F. Andrew, M. Donaldson, J. Fintzi, Dillon R. Flebbe, Evan Lamb, Amy T. Noe, S. Nurmukhambetova, Samantha J Provost, Anthony Cook, A. Dodson, Andrew Faudree, J. Greenhouse, S. Kar, Laurent Pessaint, Maciel Porto, Katelyn Steingrebe, Daniel Valentin, Serge Zouantcha, Kevin W. Bock, Mahnaz Minai, Bianca M. Nagata, R. van de Wetering, Seyhan Boyoglu-Barnum, K. Leung, Wei Shi, E. Yang, Yi Zhang, John-Paul M. Todd, Lingshu Wang, Gabriela Alvarado, H. Andersen, K. Foulds, D. Edwards, J. Mascola, Ian N. Moore, M. Lewis, A. Carfi, D. Montefiori, M. Suthar, A. McDermott, M. Roederer, N. Sullivan, D. Douek, B. Graham, R. Seder · 发表于：Science · 年份：2021 · DOI：10.1126/science.abj0299 · 被引用次数：272 · 研究领域：Medicine

Description Antibodies dovetail with protection Immune correlates of protection are clinical end points used to gauge vaccine-induced immunogenicity and protection. Corbett et al. studied nonhuman primate (NHP) immune responses to various doses of the mRNA-1273 (Moderna) vaccine to provide a range of immune responses and protective outcomes. They determined that circulating spike protein–specific antibodies correlated with protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication in the airways. Passively transferred NHP antibodies were sufficient to mediate protection against SARS-CoV-2 challenge in hamsters, emphasizing that antibodies are mechanistic correlates. Protection of the lower respiratory tract required lower serum antibody concentrations, possibly explaining why most current vaccines are highly effective against severe lower airway disease. The higher antibody threshold required for reducing upper airway infection has potential implications for boosting to limit transmission. —STS mRNA-1273 vaccine–induced antibody responses are a mechanistic correlate of protection against SARS-CoV-2 infection in nonhuman primates. INTRODUCTION Mass vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) offers the most efficient public health intervention to control the COVID-19 pandemic. Two mRNA-based vaccines, Moderna’s mRNA-1273 and Pfizer/BioNTech’s BNT162b2, both of which encode the prefusion-stabilized spike glyc...