#6794 CALCIUM/MAGNESIUM RATIO IN PATIENTS WITH DIABETES AND CHRONIC KIDNEY DISEASE: A RISK FACTOR FOR CARDIOVASCULAR DISEASE

作者：Henrique Borges, Rita Afonso, R. Marques, Teresa Jerónimo, A. Silva · 发表于：Nephrology, Dialysis and Transplantation · 年份：2023 · DOI：10.1093/ndt/gfad063d_6794 · 被引用次数：1

Chronic Kidney Disease (CKD) and Diabetes Mellitus (DM) are significant risk factors for Cardiovascular (CV) Disease. Patients with CKD and/or DM exhibit higher incidence and prevalence of CV events compared to the general population. Hypomagnesemia and elevated calcium-magnesium (Ca:Mg) ratios have been identified as independent risk factors for CV-related deaths. The aim of this study is to determine the relationship between Ca:Mg and the prognosis of CV disease in patients with CKD and DM. This cross-sectional study enrolled patients with DM and CKD followed at Diabetic Nephrology appointments in a hospital. The study population was divided into two groups: Group 1 (G1) - patients who had a previous hospitalization due to a CV event, and Group 2 (G2) - patients without CV-related hospitalizations. A logistic regression model was employed to evaluate the predictive factors for CV hospitalization for the variables studied. A total of 223 patients were included in the study, 92 females and 131 males, with an estimated glomerular filtration rate of 38.4±22 mL/min/1.73 m2 and 41% had been hospitalized due to a CV event. G1 had higher age (P = .02), higher serum phosphate (p<0.01), parathormone (p<0.01), interleukin-6 (p<0.01), FGF-23 (p<0.01), oxidized-LDL (p<0.01), Ca:Mg (p<0.01), and pulse pressure (p<0.01), as well as lower eGFR (p<0.01) and magnesium serum levels (p<0.01). The multivariate logistic regression model revealed that higher FGF-23 levels (OR=3.44, ...