Epigenetic Heritability of Cell Plasticity Drives Cancer Drug Resistance through a One-to-Many Genotype-to-Phenotype Paradigm

作者：Erica A Oliveira, S. Milite, J. Fernández-Mateos, George D. Cresswell, Erika Yara-Romero, G. Vlachogiannis, Bingjie Chen, Chela T James, Lucrezia Patruno, Gianluca Ascolani, A. Acar, Timon Heide, Inma Spiteri, Alex Graudenzi, G. Caravagna, Andrea Bertotti, Trevor A. Graham, Luca Magnani, Nicola Valeri, A. Sottoriva · 发表于：Cancer Research · 年份：2025 · DOI：10.1158/0008-5472.CAN-25-0999 · 被引用次数：28 · 研究领域：Medicine

Drug resistance is driven by genetic–epigenetic memory that enables cancer cells to adopt multiple phenotypic states depending on environmental conditions, supporting integration of evolutionary principles into biomarker discovery and personalized treatment strategies.