Ferroptosis: mechanisms and implications for cancer development and therapy response.

作者：A. F. dos Santos, Gholamreza Fazeli, Thamara Nishida Xavier da Silva, J. P. Friedmann Angeli · 发表于：Trends in Cell Biology · 年份：2023 · DOI：10.1016/j.tcb.2023.04.005 · 被引用次数：133 · 研究领域：Medicine

As cancer cells develop resistance to apoptosis, non-apoptotic cell death modalities, such as ferroptosis, have emerged as promising strategies to combat therapy-resistant cancers. Cells that develop resistance to conventional therapies or metastatic cancer cells have been shown to have increased sensitivity to ferroptosis. Therefore, targeting the regulatory elements of ferroptosis in cancer could offer novel therapeutic opportunities. In this review, we first provide an overview of the known ferroptosis regulatory networks and discuss recent findings on how they contribute to cancer plasticity. We then expand into the critical role of selenium metabolism in regulating ferroptosis. Finally, we highlight specific cases where induction of ferroptosis could be used to sensitize cancer cells to this form of cell death.