Review of bio-optical imaging systems with a high space-bandwidth product

作者：Jongchan Park, D. Brady, G. Zheng, L. Tian, Liang Gao · 发表于：Advanced Photonics · 年份：2021 · DOI：10.1117/1.AP.3.4.044001 · 被引用次数：119 · 研究领域：Engineering、Medicine

Abstract. Optical imaging has served as a primary method to collect information about biosystems across scales—from functionalities of tissues to morphological structures of cells and even at biomolecular levels. However, to adequately characterize a complex biosystem, an imaging system with a number of resolvable points, referred to as a space-bandwidth product (SBP), in excess of one billion is typically needed. Since a gigapixel-scale far exceeds the capacity of current optical imagers, compromises must be made to obtain either a low spatial resolution or a narrow field-of-view (FOV). The problem originates from constituent refractive optics—the larger the aperture, the more challenging the correction of lens aberrations. Therefore, it is impractical for a conventional optical imaging system to achieve an SBP over hundreds of millions. To address this unmet need, a variety of high-SBP imagers have emerged over the past decade, enabling an unprecedented resolution and FOV beyond the limit of conventional optics. We provide a comprehensive survey of high-SBP imaging techniques, exploring their underlying principles and applications in bioimaging.