A pneumonia outbreak associated with a new coronavirus of probable bat origin

作者：P. Zhou, Xing-Lou Yang, Xian-Guang Wang, Ben Hu, Lei Zhang, Wei Zhang, Hao-rui Si, Yan Zhu, Bei Li, Chao Huang, Hui-Dong Chen, Jing Chen, Yun Luo, Hua Guo, Ren-di Jiang, Mei Liu, Ying Chen, Xurui Shen, Xi Wang, Xiao-Shuang Zheng, Kai Zhao, Quanjiao Chen, F. Dèng, Lin-lin Liu, Bing-Ru Yan, F. Zhan, Yan-Yi Wang, Geng-Fu Xiao, Zhènglì Shí · 发表于：Nature · 年份：2020 · DOI：10.1038/s41586-020-2012-7 · 被引用次数：19753 · 研究领域：Biology、Medicine

Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats1–4. Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans5–7. Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, had caused 2,794 laboratory-confirmed infections including 80 deaths by 26 January 2020. Full-length genome sequences were obtained from five patients at an early stage of the outbreak. The sequences are almost identical and share 79.6% sequence identity to SARS-CoV. Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of SARSr-CoV. In addition, 2019-nCoV virus isolated from the bronchoalveolar lavage fluid of a critically ill patient could be neutralized by sera from several patients. Notably, we confirmed that 2019-nCoV uses the same cell entry receptor—angiotensin converting enzyme II (ACE2)—as SARS-CoV. Characterization of full-length genome sequences from patients infected with a new coronavirus (2019-nCoV) shows that the sequences are nearly identical and indicates that the virus is related to ...