Internal fixation with biodegradable high purity magnesium screws in the treatment of ankle fracture

作者：Dewei Zhao, Tian-wei Zhang, Weidan Wang, Zi-ming Wang, Fuyang Wang, Xing Yang, Ronghua Li, Liangliang Cheng, Yu Zhang, Huiyue Wang, Wangwei Zhu, Shi-Bo Huang, Wei-rong Li, L. Qin · 发表于：Journal of Orthopaedic Translation · 年份：2025 · DOI：10.1016/j.jot.2025.01.005 · 被引用次数：14 · 研究领域：Medicine

Background Metal plates and screws are widely used as internal fixations in the treatment of ankle fracture. However, there are many disadvantages such as "stress shielding" effect and the need for secondary surgical removal, which potentially affected the blood supply around the fracture site. In recent years, many studies confirmed that the biodegradable high purity magnesium (Mg) screws exhibited sufficient mechanical strength with adequate degradation rate for effective bone healing, avoiding the need for implant removal operations. Method We conducted a prospective study on patients with ankle fractures treated at Affiliated Zhongshan Hospital of Dalian University between January 2020 and January 2021. Twenty-four patients (twelve patients for each group) with ankle fractures were treated with high purity Mg screws or conventional titanium alloy plates and screws. Hematological examinations were performed in the early postoperative period, X-ray examinations were performed in the long-term postoperative follow-up. Postoperative complications, including infection, failure of internal fixation and malunion, were recorded during the follow-up. The visual analogue scale (VAS) was used to evaluate postoperative pain perceived by the patients, and the American Orthopedic Foot and Ankle Society (AOFAS) ankle-hindfoot scoring system was used to evaluate their postoperative ankle function. Results All patients achieved good fracture alignment, and imaging examination showed that ...