Normal Values for 13N-Ammonia PET-derived Metrics in Heart Transplant Patients.

作者：K. O’Gorman, L. Bremner, Zayd Mian, Lee D. Yang, Mrinali Shetty, Yosef A. Cohen, Megha Prasad, H. Rosenblum, Matthew K. Hoffman, S. Bearelly, K. Thakoor, Charissa J Chou, Yun Joo Park, Michelle Castillo, Lynne L. Johnson, Albert DeLuca, Mona P. Kinkhabwala, Qi Liu, M. Chernovolenko, Kim Goldner, Anthony Ciano, N. Uriel, Kevin J Clerkin, Andrew J. Einstein · 发表于：Journal of Nuclear Cardiology · 年份：2026 · DOI：10.1016/j.nuclcard.2026.102797 · 被引用次数：2 · 研究领域：Medicine

INTRODUCTION Cardiac PET is an established tool for detecting cardiac allograft vasculopathy (CAV), however, transplant-patient-specific normal values for myocardial blood flow (MBF), myocardial blood flow reserve (MBFR), and left ventricular parameters are limited. We aimed to define normal ranges in heart transplant (HT) recipients using two software programs and to assess agreement between software-derived metrics. METHODS We retrospectively evaluated 266 HT recipients undergoing 13N-ammonia PET between 2021-2023. Studies without ischemia or scar were included and compared with invasive coronary angiography and intravascular ultrasound. Normal values for MBF, MBFR, left ventricular volumes, and left ventricular ejection fraction were derived in patients without angiographic CAV and in a subset without micro-intimal disease, using two different software programs, Invia-4DM and Cedars-Sinai. Agreement between software-derived metrics was assessed using correlation and Bland-Altman analyses. RESULTS Ninety-three patients without angiographic CAV (56 without micro-intimal disease) met criteria for normal reference value derivation. Rate-pressure-product-correction had a significant influence on the MBFR, with lower limits of normal for uncorrected MBFR and rate-pressure-product-corrected-MBFR ranging between 1.80-2.04 and 2.10-2.37, respectively, depending on the software program and use of residual subtraction. Values of software-derived metrics demonstrated strong monoto...