Long-Term Outcomes Following Drug-Eluting Balloons Versus Thin-Strut Drug-Eluting Stents for Treatment of In-Stent Restenosis (DEB-Dragon-Registry)

作者：W. Wańha, J. Bil, R. Januszek, N. Gilis-Malinowska, Tomasz Figatowski, Marek Milewski, A. Pawlik, B. Staszczak, M. Wybraniec, B. Tomasiewicz, Piotr Kübler, W. Kuliczkowski, Tomasz Walczak, B. Hrymniak, P. Desperak, Maksymilian Mielczarek, D. Ciećwierz, P. Niezgoda, R. Wolny, M. Chudzik, Łukasz Kuźma, P. Kralisz, E. Kedhi, F. D’Ascenzo, D. Hudziak, A. Kowalówka, G. Smołka, K. Reczuch, M. Gruchała, J. Kubica, R. Gil, S. Dobrzycki, D. Dudek, Stanisław Bartuś, M. Gąsior, A. Ochała, A. Witkowski, M. Jaguszewski, W. Wojakowski · 发表于：Circulation. Cardiovascular Interventions · 年份：2021 · DOI：10.1161/CIRCINTERVENTIONS.121.010868 · 被引用次数：21 · 研究领域：Medicine

Supplemental Digital Content is available in the text. Background: Data regarding the use of percutaneous coronary intervention with drug-eluting balloons (DEB) versus thin-strut drug-eluting stents (thin-DES) for treating DES in-stent restenosis in everyday clinical practice is scarce. Our goal was to evaluate the efficacy and safety profile of DEB versus thin-DES in DES in-stent restenosis. Methods: Consecutive patients with DES in-stent restenosis who underwent percutaneous coronary intervention between 2008 and 2019 entered the multicenter DEB-DRAGON Registry with a follow-up of 3 years. Patients who received DEB at the index procedure (n=557, 49.9%) were compared with those who received thin-DES (n=560, 50.1%). Results: Analysis of the unmatched cohort revealed lower rates of target lesion revascularization (9.1% versus 13.6%; hazard ratio [HR], 0.58 [95% CI, 0.41–0.83], P=0.003), target vessel revascularization (11.8% versus 16.7%; HR, 0.62 [95% CI, 0.45–0.84], P=0.003) and device-oriented composite end point, defined as a composite of cardiac death, target lesion revascularization, and target vessel myocardial infarction (12.7% versus 16.0%; HR, 0.69 [95% CI, 0.50–0.94], P=0.018) in the thin-DES group compared with the DEB group. The incidence of cardiac death, target vessel-myocardial infarction, and myocardial infarction were similar in both groups. However, after propensity score matching, there were no significant differences in target lesion revascularization (11....