Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions

作者：E. Császár, Nikolett Lénárt, C. Cserép, Z. Környei, Rebeka Fekete, Balázs Pósfai, D. Balázsfi, B. Hangya, A. D. Schwarcz, Eszter Szabadits, D. Szöllősi, K. Szigeti, D. Máthé, B. West, Katalin Sviatkó, A. Brás, Jean-Charles Mariani, A. Kliewer, Z. Lenkei, László Hricisák, Z. Benyó, M. Baranyi, B. Sperlágh, Ákos Menyhárt, E. Farkas, Á. Dénes · 发表于：Journal of Experimental Medicine · 年份：2022 · DOI：10.1084/jem.20211071 · 被引用次数：209 · 研究领域：Medicine

Microglia modulate cerebral blood flow (CBF) through complex purinergic actions, which are mediated by dynamic, P2Y12 receptor-driven interactions with the vasculature. Microglial actions are partially independent of nitric oxide. Microglial dysfunction leads to impaired CBF response during neurovascular coupling, hypercapnia-induced vasodilation and cerebral hypoperfusion.