Transcriptomic Profiling of Hypoxia-Adaptive Responses in Tibetan Goat Fibroblasts

作者：Lin Tang, Li Zhu, Zhuzha Basang, Yunong Zhao, Shanshan Li, Xiaoyan Kong, Xiao Gou · 发表于：Animals · 年份：2025 · DOI：10.3390/ani15101407 · 被引用次数：2 · 研究领域：Medicine

Simple Summary The Tibetan goat (Capra hircus) has evolved genetic adaptations to high-altitude hypoxia. This study integrated RNA sequencing (RNA-seq), weighted gene co-expression network analysis (WGCNA), and machine learning to explore gene–environment interactions (G × E) in hypoxia adaptation. Fibroblasts derived from the Tibetan goat and lowland goat were cultured under hypoxic (1% O2) and normoxic (21% O2) conditions, revealing transcriptional plasticity as a key mechanism. Our findings provide novel insights into high-altitude livestock breeding and hypoxia-related biomedical research.