Automated vessel specific coronary artery calcification quantification with deep learning in a large multi-center registry.

作者：Michelle C. Williams, A. Shanbhag, Jian-Hang Zhou, Anna M. Michalowska, M. Lemley, Robert J. H. Miller, A. Killekar, Parker Waechter, H. Gransar, S. V. Van Kriekinge, V. Builoff, A. Feher, E. Miller, T. Bateman, D. Dey, D. Berman, P. Slomka · 发表于：European Heart Journal-Cardiovascular Imaging · 年份：2024 · DOI：10.1093/ehjci/jeae045 · 被引用次数：22 · 研究领域：Medicine

AIMS Vessel specific coronary artery calcification (CAC) is additive to global CAC for prognostic assessment. We assessed accuracy and prognostic implications of vessel-specific automated deep learning (DL) CAC analysis on electrocardiogram gated and attenuation correction computed tomography (CT) in a large multicenter registry. METHODS AND RESULTS Vessel-specific CAC was assessed in the left main/left anterior descending (LM/LAD), left circumflex (LCX) and right coronary artery (RCA) using a DL model trained on 3000 gated CT and tested on 2094 gated CT and 5969 non-gated attenuation correction CT. Vessel-specific agreement was assessed with linear weighted Cohen's Kappa for CAC zero, 1-100, 101-400 and >400 Agatston units (AU). Risk of major adverse cardiovascular events (MACE) was assessed during 2.4±1.4 years follow-up, with hazard ratios (HR) and 95% confidence intervals (CI). There was strong to excellent agreement between DL and expert ground truth for CAC in LM/LAD, LCX and RCA on gated CT [0.90 (95% CI 0.89 to 0.92); 0.70 (0.68 to 0.73); 0.79 (0.77 to 0.81)] and attenuation correction CT [(0.78 (0.77 to 0.80); 0.60 (0.58 to 0.62); 0.70 (0.68 to 0.71)]. MACE occurred in 242 (12%) undergoing gated CT and 841(14%) of undergoing attenuation correction CT. LM/LAD CAC >400 AU was associated with the highest risk of MACE on gated (HR 12.0, 95% CI 7.96, 18.0, p<0.001) and attenuation correction CT (HR 4.21, 95% CI 3.48, 5.08, p<0.001). CONCLUSION Vessel-specific CAC asse...