Can synthetic data be a proxy for real clinical trial data? A validation study

作者：Z. Azizi, Chaoyi Zheng, L. Mosquera, L. Pilote, Khaled El Emam · 发表于：BMJ Open · 年份：2021 · DOI：10.1136/bmjopen-2020-043497 · 被引用次数：101 · 研究领域：Medicine

Objectives There are increasing requirements to make research data, especially clinical trial data, more broadly available for secondary analyses. However, data availability remains a challenge due to complex privacy requirements. This challenge can potentially be addressed using synthetic data. Setting Replication of a published stage III colon cancer trial secondary analysis using synthetic data generated by a machine learning method. Participants There were 1543 patients in the control arm that were included in our analysis. Primary and secondary outcome measures Analyses from a study published on the real dataset were replicated on synthetic data to investigate the relationship between bowel obstruction and event-free survival. Information theoretic metrics were used to compare the univariate distributions between real and synthetic data. Percentage CI overlap was used to assess the similarity in the size of the bivariate relationships, and similarly for the multivariate Cox models derived from the two datasets. Results Analysis results were similar between the real and synthetic datasets. The univariate distributions were within 1% of difference on an information theoretic metric. All of the bivariate relationships had CI overlap on the tau statistic above 50%. The main conclusion from the published study, that lack of bowel obstruction has a strong impact on survival, was replicated directionally and the HR CI overlap between the real and synthetic data was 61% for over...