Primate Organoids and Gene-Editing Technologies toward Next-Generation Biomedical Research.

作者：Chuanxin Chen, W. Ji, Yuyu Niu · 发表于：Trends in Biotechnology · 年份：2021 · DOI：10.1016/j.tibtech.2021.03.010 · 被引用次数：25 · 研究领域：Medicine

The improved ability to organize pluripotent stem cells (PSCs) into 3D structures in vitro has shed light on organoid technology to recapitulate organs and tumors in vivo. Advances in gene-editing technologies, particularly CRISPR-mediated techniques, offer tremendous potential in facilitating organoid research, including the study of development, disease modeling, and personalized medicine. This review discusses how the combination of two novel technologies - organoids and gene editing - not only contributes to revealing molecular events taking place during development and tumorigenesis but also has implications for biobanking, precision medicine, and other diverse biomedical applications.