Viral dynamics in mild and severe cases of COVID-19

作者：Yang Liu, Li-meng Yan, La-gen Wan, T. Xiang, Aiping Le, Jiaming Liu, M. Peiris, L. Poon, Wei Zhang · 发表于：Lancet. Infectious Diseases (Print) · 年份：2020 · DOI：10.1016/S1473-3099(20)30232-2 · 被引用次数：1587 · 研究领域：Medicine

www.thelancet.com/infection Published online March 19, 2020 https://doi.org/10.1016/S1473-3099(20)30232-2 1 day of disease onset at the time of sampling. The DCt values of severe cases remained significantly lower for the first 12 days after onset than those of corresponding mild cases (figure A). We also studied serial samples from 21 mild and ten severe cases (figure B). Mild cases were found to have an early viral clearance, with 90% of these patients repeatedly testing negative on RT-PCR by day 10 post-onset. By contrast, all severe cases still tested positive at or beyond day 10 postonset. Overall, our data indicate that, similar to SARS in 2002–03, Viral dynamics in mild and severe cases of COVID-19