Epithelial-mesenchymal transition related to bone invasion in oral squamous cell carcinoma

作者：Jaqueline V. Vanini, L. K. Koyama, L. L. de Matos, José Martins Figueiredo Júnior, C. Cernea, C. Nagano, C. Coutinho-Camillo, R. Hsieh, S. Lourenço · 发表于：Journal of Bone Oncology · 年份：2022 · DOI：10.1016/j.jbo.2022.100418 · 被引用次数：6 · 研究领域：Medicine

Highlights • Presence of epithelial-mesenchymal transition markers in tumor-bone interface.• Dominant infiltrative pattern in bone tissue is associated with lower survival.• E-cadherin-positive cases were associated with tobacco smoking.• Vimentin-positive cases were associated with tumors under 4 cm.• Twist could be strongly involved in bone invasion and in disease progression.